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Peptide BPC-157
Improved Healing
BPC-157’s primary benefit is by and large its ability to accelerate the healing of many different wounds.
Tendons: BPC-157 was discovered to dramatically speed up the healing of tendons through the outgrowth of tendon explants and the spreading of tendon fibroblasts.
BPC-157 is also capable of healing detached or disjoined Achilles tendon.
Muscles: If you’re suffering from discomfort due to muscle sprains, tears and damage, you may find BPC-157 to be VERY useful.
In particular, one study found BPC-157 to be effective in healing quadriceps muscles that have been torn and crushed.
Muscle tears have also been observed to recover much faster with BPC-157 administration, even when the healing process is impaired by the systemic use of corticosteroids.
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Enhanced Brain Function
BPC-157 is neuroprotective, allowing for the regeneration of vital brain nerves while protecting neutrons form damage. In particular, it can even reverse damage induced by a traumatic brain injury. Combined with BPC-157’s ability to potentially heal musculoskeletal damage, this makes it a phenomenal “wonder drug” for restoring both physical and nervous function following an injury.
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Protective of Organs
BPC-157 has been shown to have a wide variety of protective effects on the organs.
Specifically, human trials found BPC-157 to demonstrate this protective effect in the prevention of gastric ulcers while also healing stomach ulcers.
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Reduced Inflammation
One of BPC-157’s remarkable properties is its ability to upregulate anti-inflammatory factors, while also reducing the production of reactive oxygen species.
In rats, BPC-157 has been shown to reduce gastrointestinal lesions in rats which were induced by non-steroidal anti-inflammatory agents. BPC-157 may also have potential for lowering inflammation in people with periodontal (tooth) disease.
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Increased Blood Flow
As stated before, BPC-157’s main mechanism of action is the promotion of angiogenesis.
In turn, this promotes the formation of new blood vessels while also releasing more nitric oxide. This function is especially useful in wounded and damaged areas of the body receiving insufficient blood flow.
This makes BPC-157 a potential candidate for healing burn wounds at a much faster rate.
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Reverses Damage Induced By NSAIDs
BPC-157 has been termed by some researchers as an antidote to nonsteroidal anti-inflammatory drugs (NSAIDs). This is due to BPC-157’s ability to counter and prevent the damaging and adverse impacts of NSAIDs such as Advil (aspirin) or ibuprofen.
Briefly, NSAIDs taken in excessively high doses can often lead to organ damage and symptoms such as vomiting, blurred vision and nausea.
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Can Combat Various Diseases
BPC-157 is a cytoprotective compound, meaning it can protect cells from foreign and/or harmful agents. This is especially observed in the digestive tract (thus making it cytoprotective), as BPC-157 can combat leaky gut via healing the brain-gut axis, inflammatory bowel disease, stomach ulcers and Crohn’s disease.
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Can Protect Your Cardiovascular System
Not only can it normalize your blood pressure regardless of whether it’s too high or low, but it can also protect blood vessels from oxidative stress.
Other cardioprotective effects include protecting cells against damaged induced by toxins, and prevention of death due to higher levels of potassium in the body.
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Peptide TB-500
Injury Healing
There is clear evidence that TB-500’s ability to heal wounds faster and more effectively while reducing tissue scarring and lowering pain at the site of injury. TB-500’s potential for regenerating damaged cells was identified as early as 1999 when a dermal study done on rats found that the peptide was able to “accelerate wound closure, increase angiogenesis, and accelerate collagen deposition”.
Organs: In addition to successfully regenerating heart tissue, TB-500 has shown promise in treating liver fibrosis (i.e. excess scarring makes the liver dysfunctional), acute ischemia-caused kidney injury (i.e. insufficient blood flow to the kidney), and acute ischemia-induced lung injury.
Skin wounds: Diabetic mice had their burn wounds healed using TB-500 in one study, while another mouse study found TB-500 could promote “full-thickness cutaneous wound healing” for extremely deep cuts… all with minimal scarring.
Ligaments: A rat study where the test subjects had a transected ligament were able to recover biochemical function and evenly regrow the collagen fibers was possible with a single treatment of TB-500.
Tissue: In two separate Phase II clinical trials involving the use of TB-500 to treat pressure and stasis ulcers, healing was faster by 30 days while also lowering inflammation and preventing re-infection.
TB-500 Mechanism of Action
There are two parts behind this peptide’s regenerative properties, as seen in numerous soft tissue injuries…
The first part of TB-500’s mechanism of action involves upregulating a cell-building protein known as “actin.”
Actin allows for the restoration and maintenance of a cell’s structure, thereby speeding up the rate at which tissue injuries heal and wounds repair themselves.
“The main functionality of TB500 hinges on the ability to upregulate cell building proteins such as actin, which is a protein that forms (together with myosin) the contractile filaments of muscle cells, and is also involved in motion and metabolism in many other types of cells.
Upregulation of actin allows TB500 to promote healing, cell growth, cell migration and cell proliferation. This not only helps build new blood vessel pathways but also upregulates the type of “good” inflammation that is directly correlated with faster wound healing.”
In other words, actin is a major part of maximum muscular contraction and it explains why bodybuilders using TB-500 “feel” stronger without having actually gained any muscle size or strength.
The second part of TB-500’s mechanism of action involves the formation of new blood vessels (i.e. angiogenesis).
It does so by promoting the expression of biomolecules such as vascular endothelial growth factor (VEGF) that stimulate blood cell development.
This consequently leads to increased blood flow, arguably the most CRITICAL part of healing any damaged tissue:
“Angiogenesis is deemed as the most important mechanism for Tβ4-induced cutaneous wound healing and cardioprotection…It is vital for tissue repair as cell survival and regeneration depends on a sufficient supply of nutrients and oxygen.”
Both parts work together synergistically in providing the TB-500 peptide with its therapeutic.
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